ATP Binding Cassette Transporter A1 (ABCA1) Antibody
312€ (60 µl)
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name
ATP Binding Cassette Transporter A1 (ABCA1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx005455
tested applications
IF/ICC
Description
ABCA1 Antibody is a Rabbit Polyclonal antibody against ABCA1. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Transporter A1 (ABCA1) |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Recommended Dilution | IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95477 |
| Gene ID | 19 |
| NCBI Accession | NP_005493.2 |
| OMIM | 205400 |
| Alias | TGD,ABC1,CERP,ABC-1,HDLDT1,HPALP1,HDLCQTL13 |
| Background | Antibody anti-ABCA1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ABCA1 is a transmembrane protein belonging to the ATP-binding cassette (ABC) transporter family, playing a vital role in lipid metabolism and cellular cholesterol efflux. It facilitates the transport of cholesterol and phospholipids from cells to apolipoproteins, such as ApoA-I, in the plasma, which is a critical step in the formation of high-density lipoprotein (HDL). Structurally, ABCA1 consists of two transmembrane domains and two ATP-binding domains that utilize ATP hydrolysis to drive lipid transport. It is highly expressed in macrophages, hepatocytes, and other cells involved in lipid metabolism. The activity of ABCA1 is essential for maintaining cellular cholesterol homeostasis and preventing lipid accumulation, particularly in macrophages, where its dysfunction can lead to foam cell formation and atherosclerosis. Mutations in the ABCA1 gene are associated with Tangier disease, a rare disorder characterized by very low HDL levels and increased susceptibility to cardiovascular disease. As a key regulator of cholesterol efflux and HDL biogenesis, ABCA1 is a therapeutic target for managing dyslipidemia and cardiovascular risk.
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