Mouse ATP Binding Cassette Transporter A1 (ABCA1) Protein

Product specifications

Proteins and Peptides

ATP Binding Cassette Transporter A1 (ABCA1)

E. coli

Mouse

Unconjugated

Molecular Weight: Calculated MW: 30.1 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Leu1404-Phe1663

Tag: N-terminal His tag

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

P41233

TGD,ABC1,CERP,ABC-1,HDLDT1,HPALP1,HDLCQTL13

Protein ABCA1

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ABCA1 is a transmembrane protein belonging to the ATP-binding cassette (ABC) transporter family, playing a vital role in lipid metabolism and cellular cholesterol efflux. It facilitates the transport of cholesterol and phospholipids from cells to apolipoproteins, such as ApoA-I, in the plasma, which is a critical step in the formation of high-density lipoprotein (HDL). Structurally, ABCA1 consists of two transmembrane domains and two ATP-binding domains that utilize ATP hydrolysis to drive lipid transport. It is highly expressed in macrophages, hepatocytes, and other cells involved in lipid metabolism. The activity of ABCA1 is essential for maintaining cellular cholesterol homeostasis and preventing lipid accumulation, particularly in macrophages, where its dysfunction can lead to foam cell formation and atherosclerosis. Mutations in the ABCA1 gene are associated with Tangier disease, a rare disorder characterized by very low HDL levels and increased susceptibility to cardiovascular disease. As a key regulator of cholesterol efflux and HDL biogenesis, ABCA1 is a therapeutic target for managing dyslipidemia and cardiovascular risk.

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