Rat A-Kinase Anchor Protein 5 (AKAP5) ELISA Kit
715€ (96 tests)
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Name
Rat A-Kinase Anchor Protein 5 (AKAP5) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx501412
Tested Applications
ELISA
Description
Rat A-Kinase Anchor Protein 5 (AKAP5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat A-kinase anchor protein 5 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Immunogen Target | A-Kinase Anchor Protein 5 (AKAP5) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P24587 |
| Alias | AKAP5, AKAP79 |
| Background | Elisa Kits for: AKAP5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Background
AKAP5, also known as AKAP79/150, is a cytosolic scaffold protein that anchors PKA, PKC, and calcineurin to the plasma membrane in neurons, cardiac tissue, and epithelial cells. AKAP5 is highly enriched in synapses, where it organizes signaling complexes that regulate synaptic plasticity, neurotransmitter release, and calcium signaling. It interacts with AMPA and NMDA receptors, ensuring the spatial regulation of PKA and PKC signaling necessary for synaptic strength and long-term potentiation (LTP), processes critical for learning and memory. AKAP5 also plays a role in cardiac function, where it regulates ion channels, such as L-type calcium channels, influencing cardiac excitation-contraction coupling. Dysregulation of AKAP5 disrupts neuronal signaling, leading to cognitive deficits, psychiatric disorders, and neurodegenerative diseases. Additionally, AKAP5 regulates receptor internalization and trafficking, highlighting its role in cellular signaling and membrane dynamics.
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