Rat 5-Hydroxytryptamine Receptor 3B (HTR3B) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Rat 5-Hydroxytryptamine Receptor 3B (HTR3B) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx500208
tested applications
ELISA
Description
Rat 5-Hydroxytryptamine Receptor 3B (HTR3B) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat 5-hydroxytryptamine receptor 3B concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | 5-Hydroxytryptamine Receptor 3B (HTR3B) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9JJ16 |
| Alias | HTR3B,5-HT3B,5-HT3B receptor |
| Background | Elisa kits for HTR3B |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
HTR3B is another subunit of the 5-HT3 receptor that assembles with HTR3A to form functional heteromeric ligand-gated ion channels. While HTR3A is essential for channel formation, HTR3B modulates the channel's electrophysiological properties, including conductance and ion permeability. This subunit is expressed in the central nervous system and gastrointestinal tract, playing a significant role in regulating emetic responses, anxiety, and nociception (pain signaling). Variants of the HTR3B gene have been linked to increased susceptibility to psychiatric conditions, including major depressive disorder (MDD) and bipolar disorder. Research has also implicated HTR3B in contributing to alcohol dependence and related behavioral traits, as it modulates reward pathways in brain regions like the nucleus accumbens. Additionally, HTR3B participates in serotonin-induced gastrointestinal motility, affecting disorders such as irritable bowel syndrome (IBS). Targeting HTR3B, either independently or in combination with HTR3A, has provided avenues for developing novel therapies to manage nausea, vomiting, and chronic pain, making it a key focus in drug development for neuropsychiatric and gastrointestinal disorders.
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