Rat 5-Hydroxytryptamine Receptor 2B / 5-HT2B (HTR2B) ELISA Kit

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Especificaciones del producto

ELISA Kits

5-Hydroxytryptamine Receptor 2B / 5-HT2B (HTR2B)

Rat

Colorimetric

Quantitative

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Standard Form: Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-15 working days.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

P30994

HTR2B,5-HT2B, 5-HT-2B, 5-HT(2B),5-HT2B receptor

Elisa Kits for: HTR2B

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

HTR2B is another subtype of the G protein-coupled serotonin receptors that modulates diverse physiological functions, including cardiovascular function, smooth muscle contraction, and mood regulation. HTR2B is expressed in the central nervous system (CNS) and peripheral tissues, particularly in the heart, liver, and gastrointestinal tract. In the CNS, it plays a role in mood stabilization and reward processing by regulating the release of neurotransmitters like dopamine. HTR2B is also critical for the development and maintenance of cardiac function, as its activation leads to cardiac hypertrophy and structural remodeling. Dysregulation of HTR2B has been linked to pulmonary hypertension, where its overactivation promotes abnormal vasoconstriction and vascular remodeling. It is also implicated in drug-induced valvular heart disease, particularly from medications like fenfluramine and MDMA (ecstasy), which act as HTR2B agonists. HTR2B’s interaction with serotonergic pathways suggests its relevance in mood disorders, impulsivity, and addiction. Genetic variants in HTR2B have been associated with behavioral abnormalities, such as aggressive impulsivity. Although less studied compared to HTR2A, HTR2B is increasingly recognized as a therapeutic target for cardiovascular disorders, mood stabilization, and conditions involving abnormal serotonin signaling, such as valvular diseases and pulmonary vascular conditions.

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