Rat 2-oxoglutarate receptor 1 (OXGR1) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for OXGR1
proveedor
Abbexareference
abx391762Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat 2-oxoglutarate receptor 1 (OXGR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat OXGR1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
OXGR1, also known as the G protein-coupled receptor 99 (GPR99), is activated by 2-oxoglutarate (α-ketoglutarate), an important intermediate in the Krebs cycle. It is predominantly expressed in the kidney, lungs, and heart, where it regulates acid-base homeostasis, metabolic sensing, and inflammatory responses. OXGR1 couples to Gq proteins, activating phospholipase C (PLC), increasing intracellular calcium levels, and modulating downstream signaling pathways. In the kidney, OXGR1 plays a key role in the regulation of bicarbonate transport and pH balance, particularly in response to metabolic acidosis. OXGR1 has also been implicated in inflammation, as α-ketoglutarate regulates immune responses through its signaling in inflammatory cells. Dysregulation of OXGR1 is associated with metabolic disorders, kidney dysfunction, and inflammatory diseases. Its emerging role as a sensor for metabolic intermediates positions OXGR1 as a potential therapeutic target for metabolic acidosis, kidney diseases, and immune-related disorders.
Características del producto
category
ELISA Kits
immunogen target
2-oxoglutarate receptor 1 (OXGR1)
reactivity
Rat
test range
78 pg/ml - 5000 pg/ml
sensitivity
< 46.9 pg/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
OXGR1,P2RY15,GPR80,GPR99,P2Y15,2-oxoglutarate receptor 1,Alpha-ketoglutarate receptor 1,G protein-coupled receptor 99,P2Y purinoceptor 15,G protein-coupled receptor 80,aKGR,CAON2
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
OXGR1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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