Human 2-oxoglutarate receptor 1 (OXGR1) ELISA Kit

Name: Human 2-oxoglutarate receptor 1 (OXGR1) ELISA Kit
Brand: Abbexa
SKU: abx385253
Price: 715 EUR
Availability: OnlineOnly

Este producto es parte de OXGR1 - 2-oxoglutarate receptor

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for OXGR1

proveedor

Abbexa

reference

abx385253

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human 2-oxoglutarate receptor 1 (OXGR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human OXGR1 concentrations in tissue homogenates, cell lysates and other biological fluids.

Background

OXGR1, also known as the G protein-coupled receptor 99 (GPR99), is activated by 2-oxoglutarate (α-ketoglutarate), an important intermediate in the Krebs cycle. It is predominantly expressed in the kidney, lungs, and heart, where it regulates acid-base homeostasis, metabolic sensing, and inflammatory responses. OXGR1 couples to Gq proteins, activating phospholipase C (PLC), increasing intracellular calcium levels, and modulating downstream signaling pathways. In the kidney, OXGR1 plays a key role in the regulation of bicarbonate transport and pH balance, particularly in response to metabolic acidosis. OXGR1 has also been implicated in inflammation, as α-ketoglutarate regulates immune responses through its signaling in inflammatory cells. Dysregulation of OXGR1 is associated with metabolic disorders, kidney dysfunction, and inflammatory diseases. Its emerging role as a sensor for metabolic intermediates positions OXGR1 as a potential therapeutic target for metabolic acidosis, kidney diseases, and immune-related disorders.

Características del producto

immunogen target

2-oxoglutarate receptor 1 (OXGR1)

reactivity

Human

test range

0.313 ng/ml - 20 ng/ml

sensitivity

< 0.188 ng/ml

assay type

Sandwich

assay data

Quantitative

form

Lyophilized

detection method

Colorimetric

sample type

Tissue homogenates, cell lysates and other biological fluids.

size 1

96 tests

alias

OXGR1,P2RY15,GPR80,GPR99,P2Y15,2-oxoglutarate receptor 1,Alpha-ketoglutarate receptor 1,G protein-coupled receptor 99,P2Y purinoceptor 15,G protein-coupled receptor 80,aKGR,CAON2

storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

or code

OXGR1

dry ice

uniprot id

https://www.uniprot.org/uniprotkb/Q96P68

gene id

https://www.ncbi.nlm.nih.gov/gene/27199

note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

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2-Oxoglutarate Receptor 1 (OXGR1) Antibody

proveedor

Abbexa

reference

abx034658

Tested Applications

ELISA, WB

reactivity

Human

status

RUO

clonality

Polyclonal

Receptor for alpha-ketoglutarate. Seems to act exclusively through a G (q) mediated pathway (By similarity).

292.5€ (80 µl)