Human 2-oxoglutarate receptor 1 (OXGR1) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Human 2-oxoglutarate receptor 1 (OXGR1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx385253
tested applications
ELISA
Description
Human 2-oxoglutarate receptor 1 (OXGR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human OXGR1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | 2-oxoglutarate receptor 1 (OXGR1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.313 ng/ml - 20 ng/ml |
| Sensitivity | < 0.188 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q96P68 |
| Gene ID | 27199 |
| OMIM | 606922 |
| Alias | OXGR1,P2RY15,GPR80,GPR99,P2Y15,2-oxoglutarate receptor 1,Alpha-ketoglutarate receptor 1,G protein-coupled receptor 99,P2Y purinoceptor 15,G protein-coupled receptor 80,aKGR,CAON2 |
| Background | Elisa kits for OXGR1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
OXGR1, also known as the G protein-coupled receptor 99 (GPR99), is activated by 2-oxoglutarate (α-ketoglutarate), an important intermediate in the Krebs cycle. It is predominantly expressed in the kidney, lungs, and heart, where it regulates acid-base homeostasis, metabolic sensing, and inflammatory responses. OXGR1 couples to Gq proteins, activating phospholipase C (PLC), increasing intracellular calcium levels, and modulating downstream signaling pathways. In the kidney, OXGR1 plays a key role in the regulation of bicarbonate transport and pH balance, particularly in response to metabolic acidosis. OXGR1 has also been implicated in inflammation, as α-ketoglutarate regulates immune responses through its signaling in inflammatory cells. Dysregulation of OXGR1 is associated with metabolic disorders, kidney dysfunction, and inflammatory diseases. Its emerging role as a sensor for metabolic intermediates positions OXGR1 as a potential therapeutic target for metabolic acidosis, kidney diseases, and immune-related disorders.
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