2-Oxoglutarate Receptor 1 (OXGR1) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
2-Oxoglutarate Receptor 1 (OXGR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx034658
tested applications
ELISA, WB
Description
Receptor for alpha-ketoglutarate. Seems to act exclusively through a G (q) mediated pathway (By similarity).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | 2-Oxoglutarate Receptor 1 (OXGR1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96P68 |
| Alias | OXGR1,P2RY15,GPR80,GPR99,P2Y15,2-oxoglutarate receptor 1,Alpha-ketoglutarate receptor 1,G protein-coupled receptor 99,P2Y purinoceptor 15,G protein-coupled receptor 80,aKGR,CAON2 |
| Background | Antibody anti-OXGR1 |
| Status | RUO |
Descripción
OXGR1, also known as the G protein-coupled receptor 99 (GPR99), is activated by 2-oxoglutarate (α-ketoglutarate), an important intermediate in the Krebs cycle. It is predominantly expressed in the kidney, lungs, and heart, where it regulates acid-base homeostasis, metabolic sensing, and inflammatory responses. OXGR1 couples to Gq proteins, activating phospholipase C (PLC), increasing intracellular calcium levels, and modulating downstream signaling pathways. In the kidney, OXGR1 plays a key role in the regulation of bicarbonate transport and pH balance, particularly in response to metabolic acidosis. OXGR1 has also been implicated in inflammation, as α-ketoglutarate regulates immune responses through its signaling in inflammatory cells. Dysregulation of OXGR1 is associated with metabolic disorders, kidney dysfunction, and inflammatory diseases. Its emerging role as a sensor for metabolic intermediates positions OXGR1 as a potential therapeutic target for metabolic acidosis, kidney diseases, and immune-related disorders.
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