Ras-Related Protein Rab-7a (RAB7) Antibody
292.5€ (80 µl)
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Name
Ras-Related Protein Rab-7a (RAB7) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx034052
Tested Applications
ELISA, WB, IHC, FCM
Description
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. RAB7 is a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Ras-Related Protein Rab-7a (RAB7) Immunogen: KLH-conjugated synthetic peptide between 176-204 amino acids from the C-terminal region of human RAB7. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/2000, IHC-P: 1/25, FCM: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 23.5 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P51149 |
| Alias | RAB7,CMT2B,PRO2706,Ras-related protein Rab-7a |
| Background | Antibody anti-RAB7A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
RAB7A, member RAS oncogene family (RAB7A) is a GTPase that plays a central role in regulating late endosomal and lysosomal trafficking, which is crucial for maintaining cellular homeostasis and protein degradation RAB7A is involved in controlling the movement of vesicles from early endosomes to late endosomes and from late endosomes to lysosomes, where materials are processed and degraded It also regulates autophagy, a cellular process responsible for the recycling of damaged organelles and proteins RAB7A’s involvement in these pathways helps control cellular signaling, immune responses, and tissue homeostasis Additionally, RAB7A has been shown to play a role in regulating the transport of key receptors involved in cell survival and immune responses Mutations or dysregulation of RAB7A are linked to several diseases, including neurodegenerative disorders, where defective vesicular transport impairs the clearance of cellular waste and leads to the accumulation of toxic substances Understanding RAB7A’s role in vesicular trafficking is critical for developing potential therapies for neurodegenerative diseases and cancer, where altered cellular transport processes contribute to disease pathogenesis
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