RAB7A, Member RAS Oncogene Family (RAB7A) Antibody
312€ (60 µl)
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Name
RAB7A, Member RAS Oncogene Family (RAB7A) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx001068
Tested Applications
WB
Description
RAB7A Antibody is a Rabbit Polyclonal antibody against RAB7A. RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: RAB7A, Member RAS Oncogene Family (RAB7A) Immunogen: A synthetic peptide corresponding to human RAB7A |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 23 kDa Observed MW: 23 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P51149 |
| Gene ID | 7879 |
| NCBI Accession | NP_004628.4 |
| Alias | RAB7,CMT2B,PRO2706,Ras-related protein Rab-7a |
| Background | Antibody anti-RAB7A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
RAB7A, member RAS oncogene family (RAB7A) is a GTPase that plays a central role in regulating late endosomal and lysosomal trafficking, which is crucial for maintaining cellular homeostasis and protein degradation RAB7A is involved in controlling the movement of vesicles from early endosomes to late endosomes and from late endosomes to lysosomes, where materials are processed and degraded It also regulates autophagy, a cellular process responsible for the recycling of damaged organelles and proteins RAB7A’s involvement in these pathways helps control cellular signaling, immune responses, and tissue homeostasis Additionally, RAB7A has been shown to play a role in regulating the transport of key receptors involved in cell survival and immune responses Mutations or dysregulation of RAB7A are linked to several diseases, including neurodegenerative disorders, where defective vesicular transport impairs the clearance of cellular waste and leads to the accumulation of toxic substances Understanding RAB7A’s role in vesicular trafficking is critical for developing potential therapies for neurodegenerative diseases and cancer, where altered cellular transport processes contribute to disease pathogenesis
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