Ras-Related protein Rab-35 (RAB35) Antibody
357.5€ (100 µg)
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Name
Ras-Related protein Rab-35 (RAB35) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx145917
Tested Applications
ELISA, WB
Description
RAB35 Antibody is a Rabbit Polyclonal against RAB35.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Ras-Related protein Rab-35 (RAB35) Immunogen: Recombinant fragment corresponding to 2-183 AA of human RAB35. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 21 kDa (Recombinant Protein) |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | BC015931 |
| Alias | RAY,H-ray,RAB1C,Ras-related protein Rab-1C,GTP-binding protein RAY,Ras-related protein Rab-35 |
| Background | Antibody anti-RAB35 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
RAB35, member RAS oncogene family (RAB35) is a small GTPase involved in regulating endocytosis, vesicle trafficking, and membrane recycling in the cell It plays an essential role in the trafficking of cellular membranes and proteins, particularly in the sorting of endosomal cargo for recycling or degradation RAB35 is also crucial in the regulation of autophagy, where it helps in the formation of autophagosomes for the degradation of dysfunctional cellular components This GTPase is involved in cellular signaling by modulating the movement of receptors and other signaling molecules to and from the cell membrane, thus influencing cell communication, adhesion, and migration RAB35’s dysfunction can result in impaired cellular homeostasis, contributing to diseases such as cancer, where disrupted vesicular trafficking supports uncontrolled cell growth and metastasis Moreover, defects in RAB35 are also linked to neurodegenerative conditions, where defective vesicular trafficking leads to cellular stress and dysfunction
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