Ragulator Complex Protein LAMTOR1 (LAMTOR1) Antibody
364€ (100 µg)
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935106861
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name
Ragulator Complex Protein LAMTOR1 (LAMTOR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx240053
tested applications
ELISA, WB, IHC
Description
Ragulator Complex Protein LAMTOR1 (LAMTOR1) Antibody is a Rabbit Polyclonal antibody for the detection of LTOR1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Ragulator Complex Protein LAMTOR1 (LAMTOR1) |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | WB: 1/200 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6IAA8 |
| Gene ID | 55004 |
| Alias | p18,PDRO,C11orf59,p27RF-Rho,Ragulator1,Lipid raft adaptor protein p18,late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 |
| Background | Antibody anti-LAMTOR1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
Ragulator complex protein LAMTOR1 is a core component of the Ragulator complex, which anchors Rag GTPases to the lysosomal membrane, functioning as a key regulator of mTORC1 signaling LAMTOR1 is essential for nutrient sensing and the activation of mTORC1, a central signaling hub that regulates cellular metabolism, growth, and autophagy in response to amino acid availability It interacts with other components of the Ragulator complex to facilitate lysosome-localized mTORC1 activation, ensuring proper coordination of anabolic and catabolic processes Dysregulation of LAMTOR1 impairs mTORC1 signaling, contributing to metabolic disorders, cancer progression, and neurodegenerative diseases where nutrient sensing and autophagic balance are disrupted LAMTOR1 is also involved in lysosomal positioning and function, highlighting its role in cellular homeostasis and stress responses Recent studies have demonstrated its involvement in immune cell activation and pathogen response, further emphasizing its critical function as a central regulator of lysosome-mTORC1 signaling and cellular metabolism
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