Ras-Related Protein Rab-6A (RAB6A) Antibody

Ras-Related Protein Rab-6A (RAB6A) Antibody

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935106861

info@markelab.com

Precio

195€ (20 µl)

Antibody anti-RAB6A

proveedor

Abbexa

reference

abx004290

Tested Applications

ELISA, WB

reactivity

Human, Mouse

status

RUO

clonality

Polyclonal

Descripción

RAB6A Antibody is a Rabbit Polyclonal antibody against RAB6A. This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.


Background

RAB6A, member RAS oncogene family (RAB6A) is another small GTPase in the RAS superfamily that is involved in regulating intracellular vesicular trafficking, particularly in the post-Golgi network RAB6A plays a critical role in the movement of vesicles from the Golgi to the plasma membrane and the sorting of secretory proteins It is involved in regulating vesicular recycling, protein transport, and the proper trafficking of signaling molecules within the cell RAB6A has also been implicated in controlling the organization of the microtubule network and in regulating the cell cycle, especially during mitosis Alterations in RAB6A expression or function are linked to several diseases, including cancer, where dysregulated vesicle trafficking and cell cycle progression contribute to tumorigenesis RAB6A’s role in regulating cellular communication and secretion further highlights its importance in both normal cellular function and the pathogenesis of various diseases

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human, Mouse


immunogen target

Ras-Related Protein Rab-6A (RAB6A)


host

Rabbit


isotype

IgG


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, WB


purification

Purified by affinity chromatography.


recommended dilution

ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.


buffer

PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.


size 1

20 µl


size 2

100 µl


size 3

2 × 100 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

RAB6A


dry ice

No


availability

Shipped within 5-10 working days.


alias

RAB6,Ras-related protein Rab-6A


NCBI accession

NP_002860.2


note

Concentration: > 0.2 mg/ml -


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