Ras-Related Protein Rab-6A (RAB6A) Antibody
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935106861
info@markelab.com
Precio
195€ (20 µl)
Antibody anti-RAB6A
proveedor
Abbexareference
abx004290Tested Applications
ELISA, WBreactivity
Human, Mousestatus
RUOclonality
PolyclonalDescripción
RAB6A Antibody is a Rabbit Polyclonal antibody against RAB6A. This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Background
RAB6A, member RAS oncogene family (RAB6A) is another small GTPase in the RAS superfamily that is involved in regulating intracellular vesicular trafficking, particularly in the post-Golgi network RAB6A plays a critical role in the movement of vesicles from the Golgi to the plasma membrane and the sorting of secretory proteins It is involved in regulating vesicular recycling, protein transport, and the proper trafficking of signaling molecules within the cell RAB6A has also been implicated in controlling the organization of the microtubule network and in regulating the cell cycle, especially during mitosis Alterations in RAB6A expression or function are linked to several diseases, including cancer, where dysregulated vesicle trafficking and cell cycle progression contribute to tumorigenesis RAB6A’s role in regulating cellular communication and secretion further highlights its importance in both normal cellular function and the pathogenesis of various diseases
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse
immunogen target
Ras-Related Protein Rab-6A (RAB6A)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB
purification
Purified by affinity chromatography.
recommended dilution
ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
size 1
20 µl
size 2
100 µl
size 3
2 × 100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
RAB6A
dry ice
No
availability
Shipped within 5-10 working days.
alias
RAB6,Ras-related protein Rab-6A
uniprot id
NCBI accession
NP_002860.2
note
Concentration: > 0.2 mg/ml -
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