Ras-Related Protein Rab-4A (RAB4A) Antibody
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935106861
info@markelab.com
Precio
383.5€ (100 µl)
Antibody anti-RAB4A
proveedor
Abbexareference
abx011709Tested Applications
ELISA, WB, IHC, FCMreactivity
Human, Mouse, Monkeystatus
RUOclonality
MonoclonalDescripción
The protein encoded by this gene belongs to the rab family. Rab4A protein is involved in the regulation of procathepsin L secretion, it was either inhibited by expression of a Rab4A dominant-negative mutant or increased by overexpression of the wild-type Rab4A in human melanoma cells.
Background
RAB4A, member RAS oncogene family (RAB4A) is a small GTPase that is part of the RAS superfamily, which plays a critical role in regulating intracellular vesicular trafficking and membrane dynamics RAB4A is particularly involved in early endosomal trafficking and recycling, contributing to the movement of endosomes between cellular compartments and facilitating the recycling of receptors and other proteins back to the plasma membrane It plays a role in the regulation of cell surface receptor availability and function, affecting processes like endocytosis, cell signaling, and vesicle trafficking Dysregulation of RAB4A has been associated with various diseases, including cancer, where altered vesicular trafficking can lead to changes in cell growth, adhesion, and migration Furthermore, RAB4A is also implicated in processes such as the immune response and neuronal signaling, making it an important protein for both immune function and cellular communication
Características del producto
category
Primary Antibodies
clonality
Monoclonal
reactivity
Human, Mouse, Monkey
immunogen target
Ras-Related Protein Rab-4A (RAB4A)
host
Mouse
isotype
IgG1
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC, FCM
purification
Purified from ascites by Protein G chromatography.
recommended dilution
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, containing 0.05% sodium azide.
size 1
100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
RAB4A
dry ice
No
availability
Shipped within 5-10 working days.
alias
RAB4,HRES1,HRES-1,HRES-1/RAB4,Ras-related protein Rab-4A
uniprot id
note
Concentration: 1 mg/ml -
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proveedor
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