Ras-Related Protein Rab-4A (RAB4A) Antibody
195€ (20 µl)
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Name
Ras-Related Protein Rab-4A (RAB4A) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx005149
Tested Applications
WB
Description
RAB4A Antibody is a Rabbit Polyclonal antibody against RAB4A. This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Ras-Related Protein Rab-4A (RAB4A) Immunogen: Synthetic peptide corresponding to RAB4A. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | WB: 1/100 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 24 kDa Observed MW: 25 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P20338 |
| Gene ID | 5867 |
| NCBI Accession | NP_004569.2 |
| OMIM | 179511 |
| Alias | RAB4,HRES1,HRES-1,HRES-1/RAB4,Ras-related protein Rab-4A |
| Background | Antibody anti-RAB4A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
RAB4A, member RAS oncogene family (RAB4A) is a small GTPase that is part of the RAS superfamily, which plays a critical role in regulating intracellular vesicular trafficking and membrane dynamics RAB4A is particularly involved in early endosomal trafficking and recycling, contributing to the movement of endosomes between cellular compartments and facilitating the recycling of receptors and other proteins back to the plasma membrane It plays a role in the regulation of cell surface receptor availability and function, affecting processes like endocytosis, cell signaling, and vesicle trafficking Dysregulation of RAB4A has been associated with various diseases, including cancer, where altered vesicular trafficking can lead to changes in cell growth, adhesion, and migration Furthermore, RAB4A is also implicated in processes such as the immune response and neuronal signaling, making it an important protein for both immune function and cellular communication
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