Ras-Related Protein Rab-43 (RAB43) Antibody

Background

RAB43, member RAS oncogene family (RAB43) is a member of the RAB family of small GTPases that plays a critical role in regulating vesicle trafficking within the cell. RAB43 is involved in the transport of vesicles between the Golgi apparatus and the endosomal system, helping to mediate protein sorting and trafficking processes essential for cellular homeostasis. This protein is particularly important for regulating the recycling and degradation of membrane proteins, which affects cellular communication and signaling. RAB43 is also implicated in the regulation of receptor endocytosis, a process that is vital for maintaining the responsiveness of cells to external stimuli. In neurons, RAB43 contributes to the movement of synaptic vesicles, ensuring the proper release and recycling of neurotransmitters. Given its role in vesicular transport, RAB43 has been linked to a variety of diseases, including cancer, where disruptions in vesicle trafficking can lead to alterations in receptor signaling pathways and contribute to tumor progression. Additionally, RAB43's involvement in cellular stress responses suggests that it may also be important in protecting cells against oxidative stress and other forms of damage, thereby playing a protective role in several degenerative diseases.