RAB26, Member RAS Oncogene Family (RAB26) Antibody
292.5€ (80 µl)
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Name
RAB26, Member RAS Oncogene Family (RAB26) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx029644
Tested Applications
ELISA, WB
Description
Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]).[supplied by OMIM].
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: RAB26, Member RAS Oncogene Family (RAB26) Immunogen: KLH-conjugated synthetic peptide between 222-248 amino acids from the C-terminal region of human RAB26. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 27.9 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9ULW5 |
| Alias | V46133,Ras-related protein Rab-26 |
| Background | Antibody anti-RAB26 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
RAB26, member RAS oncogene family (RAB26) is a GTPase that participates in regulating intracellular vesicle trafficking, contributing to processes such as protein sorting and membrane recycling RAB26 is involved in maintaining cellular homeostasis by controlling the trafficking of vesicles between cellular compartments, particularly in the endocytic and exocytic pathways It plays a role in the recycling of membrane proteins, ensuring proper receptor availability at the cell surface for signaling and internalization Furthermore, RAB26 is linked to the regulation of autophagy, the process by which cells degrade and recycle damaged organelles and proteins RAB26 helps in the proper sorting of proteins to the lysosomes, where they are degraded, contributing to cellular maintenance and stress responses This protein’s involvement in autophagy links it to diseases such as cancer and neurodegenerative disorders, where impaired vesicular trafficking and autophagy can lead to cellular dysfunction and disease progression In cancer, RAB26’s dysfunction may contribute to the accumulation of misfolded proteins and the promotion of tumor growth and metastasis
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