RAB12, Member RAS Oncogene Family (RAB12) Antibody (FITC)
169€ (20 µg)
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935106861
info@markelab.com
name
RAB12, Member RAS Oncogene Family (RAB12) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx313501
Description
RAB12 Antibody (FITC) is a Rabbit Polyclonal against RAB12 conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | RAB12, Member RAS Oncogene Family (RAB12) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6IQ22 |
| Gene ID | 201475 |
| OMIM | 616448 |
| Alias | Ras-related protein Rab-12 |
| Background | Antibody anti-RAB12 |
| Status | RUO |
Descripción
RAB12, member RAS oncogene family (RAB12) is a member of the small GTPase family and plays a crucial role in regulating vesicular trafficking and membrane dynamics RAB12 is involved in the regulation of autophagy, the process by which cells degrade and recycle damaged organelles and proteins It also contributes to the movement of late endosomes and lysosomes, ensuring proper intracellular sorting and degradation of cellular waste materials RAB12 plays a role in the trafficking of proteins between cellular compartments, especially in regulating the transport of key receptors, and is essential for maintaining cellular homeostasis Additionally, RAB12 has been shown to participate in regulating cell migration and adhesion, as its dysfunction can lead to defects in receptor recycling and membrane protein turnover RAB12’s role in vesicle trafficking and autophagy links it to neurodegenerative diseases, where impaired protein degradation and clearance lead to cellular dysfunction It is also involved in cancer biology, where altered vesicular trafficking can contribute to tumor progression, metastasis, and chemotherapy resistance
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