RAB12, Member RAS Oncogene Family (RAB12) Antibody

Product specifications

Primary Antibodies

RAB12, Member RAS Oncogene Family (RAB12)

Rabbit

Human, Mouse

WB: 1/1000, FCM: 1/25. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Purified through a protein A column, followed by peptide affinity purification.

80 µl

400 µl

Liquid

ELISA, WB, FCM

PBS containing 0.09% sodium azide.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

Q6IQ22

Ras-related protein Rab-12

Antibody anti-RAB12

RUO

Descripción

RAB12, member RAS oncogene family (RAB12) is a member of the small GTPase family and plays a crucial role in regulating vesicular trafficking and membrane dynamics RAB12 is involved in the regulation of autophagy, the process by which cells degrade and recycle damaged organelles and proteins It also contributes to the movement of late endosomes and lysosomes, ensuring proper intracellular sorting and degradation of cellular waste materials RAB12 plays a role in the trafficking of proteins between cellular compartments, especially in regulating the transport of key receptors, and is essential for maintaining cellular homeostasis Additionally, RAB12 has been shown to participate in regulating cell migration and adhesion, as its dysfunction can lead to defects in receptor recycling and membrane protein turnover RAB12’s role in vesicle trafficking and autophagy links it to neurodegenerative diseases, where impaired protein degradation and clearance lead to cellular dysfunction It is also involved in cancer biology, where altered vesicular trafficking can contribute to tumor progression, metastasis, and chemotherapy resistance

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