P2Y Purinoceptor 6 (P2RY6) Antibody
292.5€ (80 µl)
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Name
P2Y Purinoceptor 6 (P2RY6) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx028562
Tested Applications
ELISA, WB
Description
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding the same isoform have been identified for this gene.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: P2Y Purinoceptor 6 (P2RY6) Immunogen: KLH-conjugated synthetic peptide between 286-314 amino acids from the C-terminal region of human P2RY6. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 36.4 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15077 |
| Alias | P2RY6,uridine nucleotide receptor,P2Y6,P2Y ATP receptor 6,P2Y purinoceptor 6,pyrimidinergic receptor P2Y |
| Background | Antibody anti-P2RY6 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
P2RY6 is a G protein-coupled receptor activated by extracellular UDP (uridine diphosphate) and to a lesser extent UTP, mediating cellular responses to nucleotide release during tissue injury or inflammation. P2RY6 couples primarily to Gq proteins, leading to phospholipase C (PLC) activation, calcium mobilization, and downstream signaling that regulates inflammation, immune responses, and smooth muscle contraction. P2RY6 is widely expressed in immune cells, smooth muscle, and epithelial tissues, where it modulates cytokine production, chemotaxis, and vascular tone. In inflammation, P2RY6 plays a central role in recruiting immune cells and amplifying inflammatory signaling, contributing to diseases such as asthma, arthritis, and colitis. It is also involved in smooth muscle contraction in the vascular and gastrointestinal systems. Dysregulation of P2RY6 signaling is linked to chronic inflammatory diseases, cardiovascular dysfunction, and metabolic disorders. P2RY6 antagonists are being investigated as therapeutic agents for inflammation, asthma, and vascular diseases due to their role in regulating immune and smooth muscle responses.