P2Y Purinoceptor 1 (P2RY1) Antibody
637€ (100 µl)
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935106861
info@markelab.com
name
P2Y Purinoceptor 1 (P2RY1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx114925
tested applications
ELISA, WB, IHC
Description
Purinergic Receptor P2Y, G-Protein Coupled, 1 Antibody is a Rabbit Polyclonal antibody against Purinergic Receptor P2Y, G-Protein Coupled, 1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | P2Y Purinoceptor 1 (P2RY1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P47900 |
| Gene ID | 5028 |
| OMIM | 601167 |
| Alias | P2RY1,ATP receptor,P2 purinoceptor subtype Y1,P2Y purinoceptor 1,platelet ADP receptor ,Purinergic receptor P2Y1,P2Y ATP receptor 1,P2Y1 receptor,purinergic receptor P2Y,P2Y1, SARCC |
| Background | Antibody anti-P2RY1 |
| Status | RUO |
Descripción
P2RY1 is a G protein-coupled receptor (GPCR) that binds extracellular nucleotides such as ADP, acting as a key player in platelet aggregation, neurotransmission, and vascular tone. It couples to Gq proteins, activating phospholipase C (PLC) and increasing intracellular calcium levels, which triggers platelet activation and aggregation in response to ADP. P2RY1 is widely expressed in platelets, the central nervous system, and endothelial cells, where it regulates hemostasis, blood clot formation, and vasodilation. In the CNS, P2RY1 modulates neuronal excitability and synaptic transmission. Dysregulation of P2RY1 signaling is associated with thrombosis, stroke, and neuroinflammatory conditions. P2RY1 antagonists are being developed as antithrombotic agents to prevent clot formation in cardiovascular diseases. Its critical role in platelet function, vascular regulation, and neuroprotection highlights P2RY1 as a therapeutic target for thrombotic disorders and neurological diseases.
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