Proteinase-Activated Receptor 2 / PAR2 (F2RL1) Antibody
312€ (60 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Proteinase-Activated Receptor 2 / PAR2 (F2RL1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx124315
Tested Applications
WB, IF/ICC
Description
F2RL1 Antibody is a Rabbit Polyclonal Antibody against F2RL1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Proteinase-Activated Receptor 2 / PAR2 (F2RL1) Immunogen: Recombinant fusion protein corresponding to human PAR2 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/200 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 44 kDa Observed MW: 55 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P55085 |
| Gene ID | 2150 |
| NCBI Accession | NP_005233.3 |
| OMIM | 600933 |
| Alias | F2RL1,GPR11,coagulation factor II receptor-like 1,Protease-activated receptor-2 ,thrombin receptor-like 1,PAR2 |
| Background | Antibody anti-F2RL1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Proteinase-Activated Receptor 2 (F2RL1), also known as PAR2, is a G protein-coupled receptor (GPCR) activated by the cleavage of its N-terminal domain by serine proteases, such as trypsin and mast cell tryptase. PAR2 is widely expressed in various tissues, including endothelial cells, platelets, smooth muscle, and immune cells, where it regulates inflammatory responses, cell migration, and pain perception. Upon activation, F2RL1 couples to Gq, Gi, and G12/13 proteins, stimulating phospholipase C (PLC), MAPK, and Rho signaling pathways. These pathways lead to increased intracellular calcium, cell contraction, and gene expression associated with inflammation. F2RL1 plays a role in immune cell recruitment during allergic reactions, wound healing, and tissue remodeling. Dysregulation of F2RL1 has been implicated in inflammatory diseases, cancer metastasis, and pain disorders. PAR2 antagonists are being developed for therapeutic applications in conditions like asthma, chronic pain, and cancer, by modulating its pro-inflammatory effects and enhancing tissue repair.
Productos relacionados
Proteinase-Activated Receptor 2 / PAR2 (F2RL1) Antibody
Polyclonal Antibody to Proteinase-Activated Receptor 2 / PAR2 (F2RL1).…
Ver producto
Proteinase-Activated Receptor 2 / PAR2 (F2RL1) Antibody
Coagulation Factor Ii (Thrombin) Receptor-Like 1 Antibody is a Rabbit Polyclonal antibody against Coagulation Factor Ii …
Ver producto Proteinase-Activated Receptor 2 / PAR2 (F2RL1) Antibody
F2RL1 Antibody is a Rabbit Polyclonal Antibody against F2RL1.…
Ver producto