Protein Tyrosine Phosphatase Receptor Type O (PTPRO) Antibody

Este producto es parte de PTPR - protein tyrosine phosphatase receptor type
Product Graph
273€ (100 µl)

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935106861
info@markelab.com
name
Protein Tyrosine Phosphatase Receptor Type O (PTPRO) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx129825
tested applications
WB, IHC, IF/ICC

Description

Protein Tyrosine Phosphatase Receptor Type O Antibody is a Rabbit Polyclonal against Protein Tyrosine Phosphatase Receptor Type O.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Protein Tyrosine Phosphatase Receptor Type O (PTPRO)
Host
Rabbit
Reactivity
Mouse
Recommended Dilution
WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Purification
Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.
Size 1
100 µl
Size 2
200 µl
Size 3
1 ml
Form
Liquid
Tested Applications
WB, IHC, IF/ICC
Buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability
Shipped within 5-7 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
NPHS6,PTPU2,GLEPP1,PTP-OC,PTP-U2,PTPROT,R-PTP-O,Glomerular epithelial protein 1,Protein tyrosine phosphatase U2,Receptor-type tyrosine-protein phosphatase O
Background
Antibody anti-PTPRO
Status
RUO

Descripción

PTPRO, also known as GLEPP1, is a receptor-type protein tyrosine phosphatase involved in kidney function, immune regulation, and tumor suppression. Structurally, PTPRO contains extracellular Ig-like and fibronectin type III domains, a transmembrane segment, and two intracellular phosphatase domains. PTPRO is highly expressed in podocytes, specialized cells in the kidney glomerulus, where it regulates podocyte cytoskeletal organization and filtration barrier integrity. It also functions in immune cells by modulating signaling pathways related to lymphocyte activation. PTPRO has been identified as a tumor suppressor, as its loss or downregulation is associated with cancers such as lung, breast, and colorectal cancers. In the kidney, PTPRO mutations or dysfunction contribute to glomerular diseases, including nephrotic syndrome. Its role in cell growth regulation and tissue homeostasis underscores its biological importance.

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