Mouse Protein Tyrosine Phosphatase Receptor Type O (PTPRO) Protein

Este producto es parte de PTPR - protein tyrosine phosphatase receptor type
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234€ (10 µg)

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935106861
info@markelab.com
name
Mouse Protein Tyrosine Phosphatase Receptor Type O (PTPRO) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167994
tested applications
WB, SDS-PAGE

Description

Tyrosine Phosphatase Receptor Type O Protein is a recombinant Mouse protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Protein Tyrosine Phosphatase Receptor Type O (PTPRO)
Host
E. coli
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 33.9 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Phe948-Met1205

Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
E9Q612
Alias
NPHS6,PTPU2,GLEPP1,PTP-OC,PTP-U2,PTPROT,R-PTP-O,Glomerular epithelial protein 1,Protein tyrosine phosphatase U2,Receptor-type tyrosine-protein phosphatase O
Background
Protein PTPRO
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

PTPRO, also known as GLEPP1, is a receptor-type protein tyrosine phosphatase involved in kidney function, immune regulation, and tumor suppression. Structurally, PTPRO contains extracellular Ig-like and fibronectin type III domains, a transmembrane segment, and two intracellular phosphatase domains. PTPRO is highly expressed in podocytes, specialized cells in the kidney glomerulus, where it regulates podocyte cytoskeletal organization and filtration barrier integrity. It also functions in immune cells by modulating signaling pathways related to lymphocyte activation. PTPRO has been identified as a tumor suppressor, as its loss or downregulation is associated with cancers such as lung, breast, and colorectal cancers. In the kidney, PTPRO mutations or dysfunction contribute to glomerular diseases, including nephrotic syndrome. Its role in cell growth regulation and tissue homeostasis underscores its biological importance.

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