Mouse Protein Tyrosine Phosphatase Receptor Type O (PTPRO) Protein

234€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Mouse Protein Tyrosine Phosphatase Receptor Type O (PTPRO) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167994
tested applications
WB, SDS-PAGE
Description
Mouse Tyrosine Phosphatase Receptor Type O Protein is a recombinant Mouse protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Protein Tyrosine Phosphatase Receptor Type O (PTPRO) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Phe948-Met1205 Tag: N-terminal His tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 33.9 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | E9Q612 |
| Alias | NPHS6,PTPU2,GLEPP1,PTP-OC,PTP-U2,PTPROT,R-PTP-O,Glomerular epithelial protein 1,Protein tyrosine phosphatase U2,Receptor-type tyrosine-protein phosphatase O |
| Background | Protein PTPRO |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
PTPRO, also known as GLEPP1, is a receptor-type protein tyrosine phosphatase involved in kidney function, immune regulation, and tumor suppression. Structurally, PTPRO contains extracellular Ig-like and fibronectin type III domains, a transmembrane segment, and two intracellular phosphatase domains. PTPRO is highly expressed in podocytes, specialized cells in the kidney glomerulus, where it regulates podocyte cytoskeletal organization and filtration barrier integrity. It also functions in immune cells by modulating signaling pathways related to lymphocyte activation. PTPRO has been identified as a tumor suppressor, as its loss or downregulation is associated with cancers such as lung, breast, and colorectal cancers. In the kidney, PTPRO mutations or dysfunction contribute to glomerular diseases, including nephrotic syndrome. Its role in cell growth regulation and tissue homeostasis underscores its biological importance.
Related Products

PTPRO antibody
Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function(By similarity).
Ver Producto
Recombinant Human PTPRO
Ver Producto
Protein Tyrosine Phosphatase Receptor Type O (PTPRO) Antibody
PTPRO Antibody is a Rabbit Polyclonal Antibody against PTPRO.
Ver Producto