Protein Tyrosine Phosphatase Receptor Type M (PTPRM) Antibody
260€ (100 µl)
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935106861
info@markelab.com
name
Protein Tyrosine Phosphatase Receptor Type M (PTPRM) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx104381
tested applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type M (PTPRM).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Protein Tyrosine Phosphatase Receptor Type M (PTPRM) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | RPTPM,RPTPU,PTPRL1,hR-PTPu,R-PTP-MU,Protein-tyrosine phosphatase mu,Receptor-type tyrosine-protein phosphatase mu |
| Background | Antibody anti-PTPRM |
| Status | RUO |
Descripción
PTPRM, also known as RPTPμ, is a receptor-like protein tyrosine phosphatase that regulates cell-cell adhesion, signaling, and growth suppression. Structurally, PTPRM contains extracellular Ig-like and fibronectin type III domains, a transmembrane domain, and two intracellular phosphatase domains. PTPRM mediates homophilic binding, meaning it interacts with other PTPRM molecules on adjacent cells to facilitate cell-cell adhesion. It plays essential roles in maintaining tissue architecture, especially in epithelial and endothelial cells. PTPRM interacts with cadherins and catenins to regulate cell adhesion and cytoskeletal organization. Loss or downregulation of PTPRM is associated with cancer progression and metastasis due to disrupted cell adhesion. Its regulatory role in neuronal guidance and tissue integrity also highlights its importance in development and cancer biology.
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