Protein Tyrosine Phosphatase Receptor Type K (PTPRK) Antibody
273€ (100 µl)
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935106861
info@markelab.com
name
Protein Tyrosine Phosphatase Receptor Type K (PTPRK) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx131546
tested applications
WB, IHC, IF/ICC
Description
PTPRK Antibody is a Rabbit Polyclonal against PTPRK.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Protein Tyrosine Phosphatase Receptor Type K (PTPRK) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | R-PTP-kappa,PTPK,Protein-tyrosine phosphatase kappa,Receptor-type tyrosine-protein phosphatase kappa |
| Background | Antibody anti-PTPRK |
| Status | RUO |
Descripción
PTPRK is a receptor-type protein tyrosine phosphatase involved in cell adhesion, contact inhibition, and tumor suppression. Structurally, it consists of an extracellular region with multiple immunoglobulin-like (Ig) and fibronectin type III domains, a single transmembrane domain, and two intracellular phosphatase domains, where the first is catalytically active. PTPRK is predominantly expressed in epithelial tissues and the immune system. It plays a key role in regulating β-catenin signaling, which is critical for maintaining cell adhesion and inhibiting proliferation. PTPRK has been identified as a tumor suppressor, and its downregulation or loss has been associated with colorectal, lung, and breast cancers. It also participates in immune cell development, particularly T-cell maturation. By dephosphorylating key tyrosine kinases and adhesion molecules, PTPRK maintains cellular homeostasis and tissue integrity.
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