Human Protein Tyrosine Phosphatase Receptor Type K (PTPRK) Protein
234€ (10 µg)
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935106861
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name
Human Protein Tyrosine Phosphatase Receptor Type K (PTPRK) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167989
tested applications
WB, SDS-PAGE
Description
Tyrosine Phosphatase Receptor Type K Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Protein Tyrosine Phosphatase Receptor Type K (PTPRK) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 33.3 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr1185-Ser1440 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15262 |
| Alias | R-PTP-kappa,PTPK,Protein-tyrosine phosphatase kappa,Receptor-type tyrosine-protein phosphatase kappa |
| Background | Protein PTPRK |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
PTPRK is a receptor-type protein tyrosine phosphatase involved in cell adhesion, contact inhibition, and tumor suppression. Structurally, it consists of an extracellular region with multiple immunoglobulin-like (Ig) and fibronectin type III domains, a single transmembrane domain, and two intracellular phosphatase domains, where the first is catalytically active. PTPRK is predominantly expressed in epithelial tissues and the immune system. It plays a key role in regulating β-catenin signaling, which is critical for maintaining cell adhesion and inhibiting proliferation. PTPRK has been identified as a tumor suppressor, and its downregulation or loss has been associated with colorectal, lung, and breast cancers. It also participates in immune cell development, particularly T-cell maturation. By dephosphorylating key tyrosine kinases and adhesion molecules, PTPRK maintains cellular homeostasis and tissue integrity.
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