Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) Antibody
637€ (100 µl)
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Name
Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx114881
Tested Applications
ELISA, WB
Description
Protein Tyrosine Phosphatase, Receptor Type, J Antibody is a Rabbit Polyclonal antibody against Protein Tyrosine Phosphatase, Receptor Type, J.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) Immunogen: Human PTPRJ. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q12913 |
| Gene ID | 5795 |
| NCBI Accession | NP_001091973.1, NM_001098503.1, NP_002834.3, NM_002843.3 |
| OMIM | 600925 |
| Alias | DEP1,SCC1,CD148,THC10,HPTPeta,R-PTP-J,HPTP eta,R-PTP-ETA,Protein-tyrosine phosphatase receptor type J,Density-enhanced phosphatase 1,Protein-tyrosine phosphatase eta,Receptor-type tyrosine-protein phosphatase eta |
| Background | Antibody anti-PTPRJ |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Protein tyrosine phosphatase receptor type J (PTPRJ) is a transmembrane protein belonging to the protein tyrosine phosphatase family, which regulates cellular signaling pathways by dephosphorylating tyrosine residues on target proteins this receptor-like phosphatase is broadly expressed in various tissues including endothelial cells, immune cells, and epithelial cells and is implicated in controlling cell growth, adhesion, and migration it negatively regulates key signaling pathways such as those mediated by receptor tyrosine kinases including VEGFR, PDGFR, and EGFR, making it a critical player in angiogenesis, immune responses, and tumor suppression its reduced expression or functional inactivation has been associated with several cancers, including colorectal, thyroid, and breast cancers, where its loss promotes tumor progression and metastasis emerging studies suggest its role in modulating the immune microenvironment and its potential as a therapeutic target to enhance immune checkpoint therapies ongoing research focuses on elucidating its broader functions in cellular homeostasis and its utility in precision medicine.
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