Human Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) Protein
234€ (10 µg)
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Name
Human Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx068775
Tested Applications
WB, SDS-PAGE
Description
Human Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Glu1061-Gln1293 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 31.1 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q12913 |
| Alias | DEP1,SCC1,CD148,THC10,HPTPeta,R-PTP-J,HPTP eta,R-PTP-ETA,Protein-tyrosine phosphatase receptor type J,Density-enhanced phosphatase 1,Protein-tyrosine phosphatase eta,Receptor-type tyrosine-protein phosphatase eta |
| Background | Protein PTPRJ |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
Protein tyrosine phosphatase receptor type J (PTPRJ) is a transmembrane protein belonging to the protein tyrosine phosphatase family, which regulates cellular signaling pathways by dephosphorylating tyrosine residues on target proteins this receptor-like phosphatase is broadly expressed in various tissues including endothelial cells, immune cells, and epithelial cells and is implicated in controlling cell growth, adhesion, and migration it negatively regulates key signaling pathways such as those mediated by receptor tyrosine kinases including VEGFR, PDGFR, and EGFR, making it a critical player in angiogenesis, immune responses, and tumor suppression its reduced expression or functional inactivation has been associated with several cancers, including colorectal, thyroid, and breast cancers, where its loss promotes tumor progression and metastasis emerging studies suggest its role in modulating the immune microenvironment and its potential as a therapeutic target to enhance immune checkpoint therapies ongoing research focuses on elucidating its broader functions in cellular homeostasis and its utility in precision medicine.
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