Protein Tyrosine Phosphatase Receptor Type H (PTPRH) Antibody
273€ (100 µl)
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935106861
info@markelab.com
name
Protein Tyrosine Phosphatase Receptor Type H (PTPRH) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx130337
tested applications
WB, IHC, IF/ICC
Description
Protein Tyrosine Phosphatase Receptor Type H Antibody is a Rabbit Polyclonal against Protein Tyrosine Phosphatase Receptor Type H.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Protein Tyrosine Phosphatase Receptor Type H (PTPRH) |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | SAP1,R-PTP-H,Stomach cancer-associated protein tyrosine phosphatase 1,Transmembrane-type protein-tyrosine phosphatase type H,Receptor-type tyrosine-protein phosphatase H |
| Background | Antibody anti-PTPRH |
| Status | RUO |
Descripción
PTPRH, also known as stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1), is a receptor-like protein tyrosine phosphatase predominantly expressed in epithelial cells of the gastrointestinal tract. Structurally, PTPRH comprises an extracellular domain with multiple fibronectin type III repeats, a transmembrane region, and two intracellular phosphatase domains. PTPRH plays a role in epithelial cell signaling by regulating the activity of receptor tyrosine kinases, including EGFR (epidermal growth factor receptor). This regulation influences processes such as cell growth, differentiation, and migration. PTPRH is implicated in maintaining epithelial homeostasis and is overexpressed in gastrointestinal cancers, particularly gastric and colorectal cancers. Its dysregulation contributes to abnormal epithelial proliferation and cancer progression, making it a potential therapeutic target in oncology.
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