Protein Tyrosine Phosphatase Receptor Type H (PTPRH) Antibody

Este producto es parte de PTPR - protein tyrosine phosphatase receptor type
Product Graph
260€ (100 µl)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Protein Tyrosine Phosphatase Receptor Type H (PTPRH) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx128746
tested applications
WB, IHC, IF/ICC

Description

Protein Tyrosine Phosphatase Receptor Type H Antibody is a Rabbit Polyclonal against Protein Tyrosine Phosphatase Receptor Type H.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Protein Tyrosine Phosphatase Receptor Type H (PTPRH)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Purification
Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.
Size 1
100 µl
Size 2
200 µl
Size 3
1 ml
Form
Liquid
Tested Applications
WB, IHC, IF/ICC
Buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability
Shipped within 5-7 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
SAP1,R-PTP-H,Stomach cancer-associated protein tyrosine phosphatase 1,Transmembrane-type protein-tyrosine phosphatase type H,Receptor-type tyrosine-protein phosphatase H
Background
Antibody anti-PTPRH
Status
RUO

Descripción

PTPRH, also known as stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1), is a receptor-like protein tyrosine phosphatase predominantly expressed in epithelial cells of the gastrointestinal tract. Structurally, PTPRH comprises an extracellular domain with multiple fibronectin type III repeats, a transmembrane region, and two intracellular phosphatase domains. PTPRH plays a role in epithelial cell signaling by regulating the activity of receptor tyrosine kinases, including EGFR (epidermal growth factor receptor). This regulation influences processes such as cell growth, differentiation, and migration. PTPRH is implicated in maintaining epithelial homeostasis and is overexpressed in gastrointestinal cancers, particularly gastric and colorectal cancers. Its dysregulation contributes to abnormal epithelial proliferation and cancer progression, making it a potential therapeutic target in oncology.

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