Protein TMED8 (TMED8) Antibody

Este producto es parte de TMED - Transmembrane emp24 domain-containing
Product Graph
292.5€ (80 µl)

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935106861
info@markelab.com
name
Protein TMED8 (TMED8) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx028396
tested applications
ELISA, WB

Description

TMED8 Antibody is a Rabbit Polyclonal antibody against TMED8.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Protein TMED8 (TMED8)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified through a protein A column, followed by peptide affinity purification.
Size 1
80 µl
Size 2
400 µl
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS containing 0.09% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q6PL24
Alias
FAM15B, L10
Background
Antibody anti-TMED8
Status
RUO

Descripción

TMED8 is a member of the p24 family that regulates cargo trafficking and quality control within the secretory pathway, facilitating transport between the ER, ER-Golgi intermediate compartment, and Golgi apparatus. TMED8 plays an essential role in sorting and packaging cargo proteins into COPII vesicles, ensuring their efficient delivery to downstream compartments, while also mediating retrograde COPI-dependent retrieval of proteins back to the ER. TMED8 has additional roles in modulating growth factor signaling, membrane protein localization, and Golgi organization. It is expressed in a variety of tissues, particularly in rapidly proliferating cells, where it supports protein maturation, receptor signaling, and organelle homeostasis. Dysregulation of TMED8 has been associated with developmental abnormalities, cancers, and immune dysfunction due to impaired protein transport dynamics. Functional studies reveal defects in secretory pathway organization, accumulation of misfolded proteins, and disrupted signaling pathways, emphasizing its role in vesicle transport, protein quality control, and intracellular signaling.
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