Protein TMED8 (TMED8) Antibody

Background

TMED8 is a member of the p24 family that regulates cargo trafficking and quality control within the secretory pathway, facilitating transport between the ER, ER-Golgi intermediate compartment, and Golgi apparatus. TMED8 plays an essential role in sorting and packaging cargo proteins into COPII vesicles, ensuring their efficient delivery to downstream compartments, while also mediating retrograde COPI-dependent retrieval of proteins back to the ER. TMED8 has additional roles in modulating growth factor signaling, membrane protein localization, and Golgi organization. It is expressed in a variety of tissues, particularly in rapidly proliferating cells, where it supports protein maturation, receptor signaling, and organelle homeostasis. Dysregulation of TMED8 has been associated with developmental abnormalities, cancers, and immune dysfunction due to impaired protein transport dynamics. Functional studies reveal defects in secretory pathway organization, accumulation of misfolded proteins, and disrupted signaling pathways, emphasizing its role in vesicle transport, protein quality control, and intracellular signaling.