CCN Family Member 3 (CCN3) Antibody
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Description
CCN3 Antibody is a Rabbit Polyclonal Antibody against CCN3.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: CCN Family Member 3 (CCN3) Immunogen: Recombinant fusion protein corresponding to human CCN3 |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P48745 |
| Gene ID | 4856 |
| NCBI Accession | NP_002505.1 |
| OMIM | 164958 |
| Background | Antibody anti-CCN3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
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Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival(PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162). Acts by binding to integrins or membrane receptors such as NOTCH1(PubMed:12695522, PubMed:21344378, PubMed:15611078). Essential regulator of hematopoietic stem and progenitor cell function(PubMed:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway(PubMed:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling(PubMed:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration(chemotaxis) and promotes cell survival(PubMed:12695522). Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts(PubMed:15611078). Involved in bone regeneration as a negative regulator(By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification(PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion(By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway(PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis(By similarity). Attenuates inflammatory pain through regulation of IL1B-and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement(PubMed:21871891).
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CCN Family Member 3 (CCN3) Antibody
CCN3 Antibody is a Rabbit Polyclonal Antibody against CCN3.
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