CCN3 antibody
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Description
Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival(PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162). Acts by binding to integrins or membrane receptors such as NOTCH1(PubMed:12695522, PubMed:21344378, PubMed:15611078). Essential regulator of hematopoietic stem and progenitor cell function(PubMed:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway(PubMed:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling(PubMed:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration(chemotaxis) and promotes cell survival(PubMed:12695522). Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts(PubMed:15611078). Involved in bone regeneration as a negative regulator(By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification(PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion(By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway(PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis(By similarity). Attenuates inflammatory pain through regulation of IL1B-and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement(PubMed:21871891).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | nephroblastoma overexpressed gene (CCN3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 45kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P48745 |
| Gene ID | 4856 |
| Alias | CCN family member 3,Cellular communication network factor 3,Insulin-like growth factor-binding protein 9 (IBP-9, IGF-binding protein 9, IGFBP-9),Nephro blastoma-overexpressed gene protein homolog,Protein NOV homolog (NovH),CCN3,IGFBP9,NOV,NOVH |
| Background | Antibody anti-CCN3 |
| Status | RUO |
| Note | Mol. Weight 45 kDa |
Descripción
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CCN3 antibody
Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival(PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162). Acts by binding to integrins or membrane receptors such as NOTCH1(PubMed:12695522, PubMed:21344378, PubMed:15611078). Essential regulator of hematopoietic stem and progenitor cell function(PubMed:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway(PubMed:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling(PubMed:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration(chemotaxis) and promotes cell survival(PubMed:12695522). Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts(PubMed:15611078). Involved in bone regeneration as a negative regulator(By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification(PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion(By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway(PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis(By similarity). Attenuates inflammatory pain through regulation of IL1B-and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement(PubMed:21871891).
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