Protein C Receptor, Endothelial (PROCR) Antibody
Pida mas información
935106861
info@markelab.com
Precio
195€ (20 µl)
Antibody anti-PROCR
proveedor
Abbexareference
abx004411Tested Applications
ELISA, WBreactivity
Human, Mousestatus
RUOclonality
PolyclonalDescripción
PROCR Antibody is a Rabbit Polyclonal antibody against PROCR. The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer.
Background
PROCR, also known as the endothelial protein C receptor (EPCR), is a critical component of the protein C anticoagulant pathway. This pathway has essential roles in regulating blood coagulation, inflammation, and maintaining vascular integrity. PROCR is primarily expressed on endothelial cells lining blood vessels and binds to activated protein C (APC) to enhance its anticoagulant effects. This interaction is vital for limiting thrombosis, mitigating inflammation, and preserving the barrier function of blood vessels, especially in response to inflammatory and coagulatory challenges. Recent research has revealed additional roles for PROCR, including functions in immune response modulation, cell proliferation, and tissue regeneration.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse
immunogen target
Protein C Receptor, Endothelial (PROCR)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB
purification
Purified by affinity chromatography.
recommended dilution
ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
size 1
20 µl
size 2
100 µl
size 3
2 × 100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
PROCR
dry ice
No
availability
Shipped within 5-10 working days.
alias
CCCA,EPCR,CCD41,Endothelial protein C receptor, Activated protein C receptor,APC receptor,Endothelial cell protein C receptor
uniprot id
NCBI accession
NP_006395.2
note
Concentration: > 0.2 mg/ml -
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