Protein BRICK1 (BRK1) Antibody
260€ (50 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Protein BRICK1 (BRK1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx212959
tested applications
ELISA, IHC
Description
BRK1 Antibody is a Rabbit Polyclonal against BRK1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Protein BRICK1 (BRK1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8WUW1 |
| Gene ID | 55845 |
| Alias | MDS027,hHBrk1,C3orf10,HSPC300,Protein BRICK1 |
| Background | Antibody anti-BRK1 |
| Status | RUO |
Descripción
BRICK1 subunit of SCAR/WAVE actin nucleating complex (BRK1) is a protein that is a part of the SCAR/WAVE complex, which regulates actin polymerization by activating the Arp2/3 complex The SCAR/WAVE complex, including BRICK1, is involved in initiating the formation of branched actin filaments, a process essential for cell movement, membrane ruffling, and cellular shape changes BRICK1 plays a role in promoting actin dynamics, particularly in immune cells where it influences processes such as T-cell activation, cell migration, and phagocytosis In addition, BRICK1 is important for neuronal development, where it helps regulate synaptic plasticity and dendritic spine morphology Disruption of BRICK1 or the SCAR/WAVE complex can lead to defects in cell motility, immune function, and nervous system development Abnormal regulation of actin dynamics due to BRICK1 dysfunction is implicated in various diseases, including autoimmune disorders, cancer metastasis, and neurodevelopmental disorders where impaired cellular movement and actin remodeling contribute to disease progression
