Prostaglandin F2 Receptor Negative Regulator (PTGFRN) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Prostaglandin F2 Receptor Negative Regulator (PTGFRN) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx030330
tested applications
ELISA, WB
Description
PTGFRN inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Prostaglandin F2 Receptor Negative Regulator (PTGFRN) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9P2B2 |
| Alias | Prostaglandin F2 receptor negative regulator,FPRP,CD315,EWI-F,CD9P-1,SMAP-6,CD9 partner 1,Glu-Trp-Ile EWI motif-containing protein F |
| Background | Antibody anti-PTGFRN |
| Status | RUO |
Descripción
Prostaglandin F2 receptor inhibitor (PTGFRN), also known as CD315 or FPRP (Fas-associated protein response-related protein), is a transmembrane protein associated with prostaglandin receptor signaling. PTGFRN is known primarily for its ability to modulate prostaglandin F2 alpha (PGF2α) receptor function, thereby impacting prostaglandin signaling pathways involved in inflammatory responses, immune modulation, and reproductive processes. PTGFRN doesn’t directly bind prostaglandins but instead influences PGF2α receptor function indirectly, regulating cellular responses to prostaglandins by modifying receptor sensitivity and availability on the cell surface. PTGFRN has a wide tissue distribution and is expressed in cells of the immune system, cardiovascular tissues, reproductive organs, and certain epithelial tissues. Its role extends beyond prostaglandin modulation, as it’s also involved in various cellular processes including cell adhesion, migration, and interactions with other membrane proteins, such as tetraspanins. PTGFRN is therefore relevant in inflammatory diseases, reproductive health, cardiovascular function, and potentially in cancer.
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