Prolactin-Releasing Peptide Receptor (PRLHR) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Prolactin-Releasing Peptide Receptor (PRLHR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015471
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against PRLHR protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Prolactin-Releasing Peptide Receptor (PRLHR) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/20000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49683 |
| Alias | PRLHR,PrRPR,GPR10,G protein-coupled receptor 10,prRP receptor |
| Background | Antibody anti-PRLHR |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
PRLHR, also known as the G protein-coupled receptor for prolactin-releasing peptide (PrRP), regulates energy homeostasis, stress responses, and endocrine functions. PRLHR is predominantly expressed in the hypothalamus and brainstem, where it modulates prolactin release, appetite suppression, and metabolic processes. PRLHR couples to Gq proteins, activating phospholipase C (PLC), increasing intracellular calcium, and stimulating downstream pathways involved in neurotransmission and hormone regulation. Beyond prolactin release, PRLHR plays a role in regulating feeding behavior by acting as an anorexigenic signal that reduces food intake and promotes energy expenditure. PRLHR is also implicated in cardiovascular regulation and stress-related behaviors through its actions in the autonomic nervous system. Dysregulation of PRLHR has been linked to obesity, metabolic syndrome, and stress disorders. Therapeutic targeting of PRLHR is being explored for obesity management and metabolic disorders, as its activation can enhance satiety and improve energy balance while modulating neuroendocrine responses.
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