Pregnancy Zone Protein (PZP) Antibody
286€ (100 µl)
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Name
Pregnancy Zone Protein (PZP) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx102181
Tested Applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to Pregnancy Zone Protein (PZP).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Pregnancy Zone Protein (PZP) Immunogen: PZP (Tyr1224-Ala1495) |
| Host | Rabbit |
| Reactivity | Mouse |
| Assay Type | Concentration: 0.86 mg/ml |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q61838 |
| Alias | CPAMD6,pregnancy zone protein,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6 |
| Background | Antibody anti-PZP |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PZP alpha-2-macroglobulin like (PZP) is a protein that shares structural similarities with alpha-2-macroglobulin, a major inhibitor of proteases in the blood, and functions in regulating immune responses and tissue repair PZP is involved in inhibiting a wide range of proteases, including those involved in inflammation and coagulation, thereby preventing tissue damage caused by excessive protease activity It is expressed in various tissues, including the liver and brain, and has been shown to modulate immune cell activation and inflammatory processes PZP’s role in protease inhibition also extends to its involvement in preventing excessive tissue degradation during injury and infection, contributing to wound healing and tissue remodeling Dysregulation of PZP expression has been linked to inflammatory diseases, including autoimmune conditions, where its altered levels can exacerbate inflammation and tissue damage Furthermore, PZP has been implicated in cancer, where it may influence tumor progression by regulating protease activity within the tumor microenvironment Studies suggest that PZP may also have neuroprotective effects, particularly in diseases like Alzheimer’s, where it modulates protease activity in the brain to reduce neuronal damage
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