Potassium Channel Tetramerization Domain Containing 12 (KCTD12) Antibody

Product specifications

Primary Antibodies

Potassium Channel Tetramerization Domain Containing 12 (KCTD12)

Rabbit

Human

WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Purified through a protein A column, followed by peptide affinity purification.

80 µl

400 µl

Liquid

ELISA, WB, IHC, FCM

PBS containing 0.09% sodium azide.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

Q96CX2

KCTD12,PFET1,PFETIN,C13orf2

Antibody anti-KCTD12

RUO

Descripción

KCTD12 is a member of the potassium channel tetramerization domain (KCTD) family and functions as an auxiliary subunit of GABA-B receptors. KCTD12 modulates GABA-B receptor signaling by accelerating activation and desensitization kinetics, fine-tuning inhibitory neurotransmission in the central nervous system. It is predominantly expressed in brain regions involved in cognition, sensory processing, and motor control, where it regulates synaptic inhibition and neuronal excitability. KCTD12 also interacts with various proteins through its BTB/POZ domain, contributing to cellular processes like ubiquitination and transcriptional regulation. Beyond its role in neurotransmission, KCTD12 has been implicated in cancer, particularly gastrointestinal stromal tumors (GISTs), where its expression influences tumor cell proliferation and survival. In psychiatric disorders, such as anxiety and depression, altered KCTD12 expression disrupts GABA-B receptor-mediated signaling, impairing inhibitory balance in neural circuits. Its role as a GABA-B receptor modulator and involvement in protein-protein interactions highlights KCTD12 as a key regulator of neuronal function and a potential therapeutic target for neurological disorders and cancer.

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