Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) Antibody

Este producto es parte de ALOX - Arachidonate lipoxygenase
Product Graph
292.5€ (50 µl)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx033749
tested applications
ELISA, WB, IHC, IF/ICC

Description

ALOX15 converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid. The protein also acts on C-12 of arachidonate as well as on linoleic acid.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified Rabbit Polyclonal Antibody.
Size 1
50 µl
Size 2
200 µl
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF/ICC
Buffer
PBS containing 0.09% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P16050
NCBI Accession
NP_001131.3
Alias
ALOX15,LOG15
Background
Antibody anti-ALOX15
Status
RUO

Descripción

ALOX15 catalyzes the oxygenation of arachidonic acid and linoleic acid to generate 15(S)-hydroperoxyeicosatetraenoic acid [15(S)-HPETE] and 13(S)-hydroxyoctadecadienoic acid (13(S)-HODE), respectively. These lipid intermediates are precursors for resolvins, protectins, and other specialized pro-resolving mediators (SPMs) involved in the resolution of inflammation. ALOX15 is highly expressed in reticulocytes, macrophages, and epithelial cells, where it plays roles in redox regulation, membrane remodeling, and anti-inflammatory responses. In macrophages, ALOX15 promotes the clearance of apoptotic cells (efferocytosis) and contributes to tissue homeostasis during inflammation resolution. Dysregulation of ALOX15 is associated with various pathological conditions, including asthma, atherosclerosis, diabetes, and neurodegenerative diseases. In cancer biology, ALOX15 has dual roles, acting as both a tumor suppressor by inhibiting proliferation and a pro-tumorigenic factor in specific contexts. Its ability to generate lipid mediators essential for resolving inflammation highlights its therapeutic potential in chronic inflammatory and metabolic disorders.

Related Products

EH0204

Human 15-LO (Arachidonate 15-Lipoxygenase) ELISA Kit

Ver Producto
EM1621

Mouse 15-LO/LOX (15-lipoxygenase) ELISA Kit

Ver Producto
ER1553

Rat Alox15 (Polyunsaturated fatty acid lipoxygenase ALOX15) ELISA Kit

Ver Producto