Human Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) Protein
247€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Human Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx065449
Tested Applications
WB, SDS-PAGE
Description
Human Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) Protein is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Lys170-Leu312 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 17.3 kDa Observed MW (SDS-PAGE): 17 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P16050 |
| Gene ID | 246 |
| Alias | ALOX15,LOG15 |
| Background | Protein ALOX15 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 350 µg/ml |
Background
ALOX15 catalyzes the oxygenation of arachidonic acid and linoleic acid to generate 15(S)-hydroperoxyeicosatetraenoic acid [15(S)-HPETE] and 13(S)-hydroxyoctadecadienoic acid (13(S)-HODE), respectively. These lipid intermediates are precursors for resolvins, protectins, and other specialized pro-resolving mediators (SPMs) involved in the resolution of inflammation. ALOX15 is highly expressed in reticulocytes, macrophages, and epithelial cells, where it plays roles in redox regulation, membrane remodeling, and anti-inflammatory responses. In macrophages, ALOX15 promotes the clearance of apoptotic cells (efferocytosis) and contributes to tissue homeostasis during inflammation resolution. Dysregulation of ALOX15 is associated with various pathological conditions, including asthma, atherosclerosis, diabetes, and neurodegenerative diseases. In cancer biology, ALOX15 has dual roles, acting as both a tumor suppressor by inhibiting proliferation and a pro-tumorigenic factor in specific contexts. Its ability to generate lipid mediators essential for resolving inflammation highlights its therapeutic potential in chronic inflammatory and metabolic disorders.
Productos relacionados
Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) Antibody
This product is currently in development. The lead time for this product may be several months. Please contact us at…
Ver producto
Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) Antibody
ALOX15 converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid. The protein also acts on C-12 of arachidonate …
Ver producto Human Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) Protein
Human Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) Protein is a recombinant Human protein expressed in E. col…
Ver producto