Human Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) Protein

Este producto es parte de ALOX - Arachidonate lipoxygenase
Human Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) Protein

Pida mas información

935106861

info@markelab.com

Precio

247€ (10 µg)

Protein ALOX15

proveedor

Abbexa

reference

abx065449

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human Arachidonate-15-Lipoxygenase (ALOX15) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

ALOX15 catalyzes the oxygenation of arachidonic acid and linoleic acid to generate 15(S)-hydroperoxyeicosatetraenoic acid [15(S)-HPETE] and 13(S)-hydroxyoctadecadienoic acid (13(S)-HODE), respectively. These lipid intermediates are precursors for resolvins, protectins, and other specialized pro-resolving mediators (SPMs) involved in the resolution of inflammation. ALOX15 is highly expressed in reticulocytes, macrophages, and epithelial cells, where it plays roles in redox regulation, membrane remodeling, and anti-inflammatory responses. In macrophages, ALOX15 promotes the clearance of apoptotic cells (efferocytosis) and contributes to tissue homeostasis during inflammation resolution. Dysregulation of ALOX15 is associated with various pathological conditions, including asthma, atherosclerosis, diabetes, and neurodegenerative diseases. In cancer biology, ALOX15 has dual roles, acting as both a tumor suppressor by inhibiting proliferation and a pro-tumorigenic factor in specific contexts. Its ability to generate lipid mediators essential for resolving inflammation highlights its therapeutic potential in chronic inflammatory and metabolic disorders.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 17.3 kDa Observed MW: 17 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys170-Leu312 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ALOX15


dry ice

No


availability

Shipped within 5-7 working days.


alias

ALOX15,LOG15


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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