Polyunsaturated Fatty Acid 5-Lipoxygenase Phospho-Ser523 (ALOX5 pS523) Antibody
429€ (100 µl)
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Name
Polyunsaturated Fatty Acid 5-Lipoxygenase Phospho-Ser523 (ALOX5 pS523) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx333563
Tested Applications
ELISA, WB
Description
ALOX5 (pS523) Antibody is a Rabbit Polyclonal against ALOX5 (pS523).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Polyunsaturated Fatty Acid 5-Lipoxygenase Phospho-Ser523 (ALOX5 pS523) Immunogen: Peptide sequence around phosphorylation site of serine 523 (R-K-S (p)-K-G) derived from Human ALOX5. |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Recommended Dilution | WB: 1/500 - 1/3000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P09917 |
| Gene ID | 240 |
| Alias | ALOX5,LOG5 |
| Background | Antibody anti-ALOX5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ALOX5 is a key enzyme in the biosynthesis of leukotrienes, potent lipid mediators involved in inflammation, immune responses, and allergic reactions. ALOX5 catalyzes the oxidation of arachidonic acid to form 5-hydroperoxyeicosatetraenoic acid (5-HPETE), which is subsequently converted into leukotriene A4 (LTA4), the precursor for leukotrienes B4 (LTB4), C4 (LTC4), D4, and E4. These leukotrienes play significant roles in recruiting neutrophils, promoting vascular permeability, and inducing smooth muscle contraction. ALOX5 is highly expressed in immune cells such as neutrophils, eosinophils, and macrophages, where it mediates inflammatory responses to infection, injury, and allergens. Dysregulation of ALOX5 is associated with asthma, rheumatoid arthritis, atherosclerosis, and cancer, where leukotrienes amplify inflammation and promote tissue damage. In cancer, ALOX5 enhances tumor cell proliferation, survival, and angiogenesis through lipid signaling. As such, ALOX5 inhibitors, including zileuton, are used therapeutically for asthma and are being explored for anti-cancer treatments targeting lipid metabolism.
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