Mouse Polyunsaturated Fatty Acid 5-Lipoxygenase (ALOX5) Protein
221€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Mouse Polyunsaturated Fatty Acid 5-Lipoxygenase (ALOX5) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx065450
Tested Applications
WB, SDS-PAGE
Description
Mouse Arachidonate-5-Lipoxygenase (ALOX5) is a recombinant Mouse protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Polyunsaturated Fatty Acid 5-Lipoxygenase (ALOX5) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Leu374-Leu536 Tag: N-terminal His tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 20.1 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P48999 |
| Alias | ALOX5,LOG5 |
| Background | Protein ALOX5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
ALOX5 is a key enzyme in the biosynthesis of leukotrienes, potent lipid mediators involved in inflammation, immune responses, and allergic reactions. ALOX5 catalyzes the oxidation of arachidonic acid to form 5-hydroperoxyeicosatetraenoic acid (5-HPETE), which is subsequently converted into leukotriene A4 (LTA4), the precursor for leukotrienes B4 (LTB4), C4 (LTC4), D4, and E4. These leukotrienes play significant roles in recruiting neutrophils, promoting vascular permeability, and inducing smooth muscle contraction. ALOX5 is highly expressed in immune cells such as neutrophils, eosinophils, and macrophages, where it mediates inflammatory responses to infection, injury, and allergens. Dysregulation of ALOX5 is associated with asthma, rheumatoid arthritis, atherosclerosis, and cancer, where leukotrienes amplify inflammation and promote tissue damage. In cancer, ALOX5 enhances tumor cell proliferation, survival, and angiogenesis through lipid signaling. As such, ALOX5 inhibitors, including zileuton, are used therapeutically for asthma and are being explored for anti-cancer treatments targeting lipid metabolism.
Productos relacionados
Polyunsaturated Fatty Acid 5-Lipoxygenase (ALOX5) Antibody
ALOX5 Antibody is a Rabbit Polyclonal antibody against ALOX5. This gene encodes a member of the lipoxygenase gene family…
Ver producto Mouse Polyunsaturated Fatty Acid 5-Lipoxygenase (ALOX5) Protein
Mouse Arachidonate-5-Lipoxygenase (ALOX5) is a recombinant Mouse protein expressed in E. coli.…
Ver producto Mouse Polyunsaturated Fatty Acid 5-Lipoxygenase (ALOX5) Protein
Mouse Arachidonate-5-Lipoxygenase (ALOX5) is a recombinant Mouse protein expressed in E. coli.…
Ver producto