Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) Antibody

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Description
Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) Antibody is a Rabbit polyclonal antibody for the detection of Human Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1).
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Product specifications
Category | Primary Antibodies |
Immunogen Target | Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) |
Host | Rabbit |
Reactivity | Human |
Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Size 1 | 50 µg |
Size 2 | 100 µg |
Form | Liquid |
Tested Applications | ELISA, WB, IHC |
Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
Availability | Shipped within 5-12 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | Q92508 |
Gene ID | 9780 |
NCBI Accession | NP_001136336.2 |
Background | Antibody anti-PIEZO1 |
Status | RUO |
Descripción
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PIEZO1 antibody
Pore-forming subunit of a mechanosensitive non-specific cation channel(PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling(PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation(PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology(By similarity).
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Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) Antibody
PIEZO1 Antibody is a Rabbit Polyclonal Antibody against PIEZO1.
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Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) Antibody
PIEZO1 Antibody is a Rabbit Polyclonal against PIEZO1.
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