Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) Antibody
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Description
PIEZO1 Antibody is a Rabbit Polyclonal Antibody against PIEZO1.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92508 |
| Gene ID | 9780 |
| NCBI Accession | NP_001136336.2 |
| Background | Antibody anti-PIEZO1 |
| Status | RUO |
| Note | Concentration: 2.01 mg/ml - |
Descripción
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PIEZO1 antibody
Pore-forming subunit of a mechanosensitive non-specific cation channel(PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling(PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation(PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology(By similarity).
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Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) Antibody
PIEZO1 Antibody is a Rabbit Polyclonal Antibody against PIEZO1.
Ver Producto
Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) Antibody
PIEZO1 Antibody is a Rabbit Polyclonal against PIEZO1.
Ver Producto