PIEZO1 antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Pore-forming subunit of a mechanosensitive non-specific cation channel(PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling(PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation(PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology(By similarity).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | family with sequence similarity 38, member A (PIEZO1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:200-1:1000; IHC: 1:50-1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 250kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB,IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q92508 |
| Gene ID | 9780 |
| Alias | Piezo-type mechanosensitive ion channel component 1,Membrane protein induced by beta-amyloid treatment (Mib),Protein FAM38A,PIEZO1,FAM38A,KIAA0233 |
| Background | Antibody anti-PIEZO1 |
| Status | RUO |
| Note | Mol. Weight 250 kDa |
Descripción
Related Products
PIEZO1 antibody
Pore-forming subunit of a mechanosensitive non-specific cation channel(PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling(PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation(PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology(By similarity).
Ver Producto
Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) Antibody
PIEZO1 Antibody is a Rabbit Polyclonal Antibody against PIEZO1.
Ver Producto
Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) Antibody
PIEZO1 Antibody is a Rabbit Polyclonal against PIEZO1.
Ver Producto