Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) Antibody
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Description
PIEZO1 Antibody is a Rabbit Polyclonal against PIEZO1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92508 |
| Gene ID | 9780 |
| OMIM | 194380 |
| Background | Antibody anti-PIEZO1 |
| Status | RUO |
| Note | Concentration: 1.85 mg/ml - |
Descripción
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PIEZO1 antibody
Pore-forming subunit of a mechanosensitive non-specific cation channel(PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling(PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation(PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology(By similarity).
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Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) Antibody
PIEZO1 Antibody is a Rabbit Polyclonal Antibody against PIEZO1.
Ver Producto
Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) Antibody
PIEZO1 Antibody is a Rabbit Polyclonal against PIEZO1.
Ver Producto