Phospholipase ABHD3 (ABHD3) Antibody

Background

ABHD3 is a serine hydrolase that plays a significant role in lipid metabolism by hydrolyzing medium- and long-chain fatty acid esters of lysophosphatidylcholine (LPC), a major bioactive lipid. Expressed in tissues such as the liver, lungs, and brain, ABHD3 regulates LPC levels, thereby influencing inflammation, cell signaling, and membrane fluidity. The enzyme is involved in maintaining lipid homeostasis, ensuring balanced levels of bioactive lipids to prevent lipid-mediated toxicity and cellular stress. Dysregulation of ABHD3 has been associated with chronic inflammatory diseases and metabolic disorders, highlighting its critical role in modulating lipid-related processes. ABHD3 also interacts with other lipid-metabolizing enzymes to fine-tune lipid signaling pathways, making it a potential target for therapeutic intervention in diseases involving inflammation, lipid dysregulation, and membrane dysfunction. Its structural design emphasizes its specificity and efficiency in lipid hydrolysis, underscoring its functional importance in cellular health.