PHD Finger Protein 8 (PHF8) Antibody
286€ (100 µl)
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935106861
info@markelab.com
name
PHD Finger Protein 8 (PHF8) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx131696
tested applications
WB, IHC, IF/ICC
Description
PHD Finger Protein 8 Antibody is a Rabbit Polyclonal against PHD Finger Protein 8.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PHD Finger Protein 8 (PHF8) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q80TJ7 |
| Alias | JHDM1F,KDM7B MRXSSD,ZNF422,Histone lysine demethylase PHF8 |
| Background | Antibody anti-PHF8 |
| Status | RUO |
Descripción
PHF8 is a histone demethylase containing a PHD finger domain that recognizes H3K4me3 and demethylates repressive marks such as H3K9me2/1 to activate transcription. It plays a role in gene regulation during cell cycle progression, neuronal development, and DNA damage repair by promoting chromatin accessibility. PHF8 is expressed in neural tissues and contributes to neurogenesis, synaptic plasticity, and cognitive function. Mutations in PHF8 are associated with X-linked intellectual disability and cleft lip/palate syndromes, where impaired histone demethylation leads to defective gene expression during development. Dysregulation of PHF8 is also implicated in cancer, where it promotes tumor growth and proliferation through transcriptional activation of oncogenes. Knockdown studies demonstrate impaired DNA repair, cell cycle arrest, and defects in neuronal differentiation, highlighting its critical role in histone demethylation, chromatin regulation, and developmental processes.
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